Core Activities
The Marignani Discovery Research Laboratory is interested in molecular mechanisms of...
01
Breast, lung and pancreatic cancers
02
neurodegenerative diseases
03
molecular processes that permit cells to migrate
Platforms
single-cell RNA-seq (scRNA-seq)
scATAC-seq
proteomics
metabolomics
epigenomics
immunobiology
whole genome manipulation
gene-editing (CRISPR-Cas9 and shRNA)
transgenic and Cas9 mouse models of human diseases
cell imaging
protein, DNA, and virus manipulations
high through-put screening strategies
- Pre-clinical trials, metronomic dosing, small animal imaging
- Innovation through technology development and refining
- Dissemination of new knowledge: peer-reviewed publications, invited plenary speaker, academic seminar speaker, public outreach
- Mentoring and training of future scientist and medical doctors. Leadership and career development
- Education of stakeholders: people with diseases, their families and friends, community and policy makers
- Resource acquisition and management