Core Activities

The Marignani Discovery Research Laboratory is interested in molecular mechanisms of...

Platforms

  • single-cell RNA-seq (scRNA-seq)

  • scATAC-seq

  • proteomics

  • metabolomics

  • epigenomics

  • immunobiology

  • whole genome manipulation

  • gene-editing (CRISPR-Cas9 and shRNA)

  • transgenic and Cas9 mouse models of human diseases

  • cell imaging

  • protein, DNA, and virus manipulations

  • high through-put screening strategies

    • Pre-clinical trials, metronomic dosing, small animal imaging
    • Innovation through technology development and refining
    • Dissemination of new knowledge: peer-reviewed publications, invited plenary speaker, academic seminar speaker, public outreach
    • Mentoring and training of future scientist and medical doctors. Leadership and career development
    • Education of stakeholders: people with diseases, their families and friends, community and policy makers
    • Resource acquisition and management